{"id":5863,"date":"2019-08-07T08:01:01","date_gmt":"2019-08-07T06:01:01","guid":{"rendered":"https:\/\/wordpress-famicord-ch.empressia.dev\/pregnancy-zone-2\/%pregnancy_zone_category%\/nabelschnurblut-rettet-maedchen-mit-schwerer-pulmonaler-hypertonie"},"modified":"2026-01-22T15:47:51","modified_gmt":"2026-01-22T14:47:51","slug":"nabelschnurblut-rettet-maedchen-mit-schwerer-pulmonaler-hypertonie","status":"publish","type":"pregnancy_zone","link":"https:\/\/famicord.lu\/fr\/pregnancy-zone-2\/news-fr\/nabelschnurblut-rettet-maedchen-mit-schwerer-pulmonaler-hypertonie","title":{"rendered":"Le sang de cordon ombilical sauve une fillette atteinte d’hypertension pulmonaire s\u00e9v\u00e8re"},"content":{"rendered":"

Hypertension pulmonaire – de quoi s’agit-il ?<\/strong><\/h2>\n

L’hypertension art\u00e9rielle pulmonaire (HTAP) est actuellement une maladie incurable. Elle entra\u00eene la mort dans les cinq \u00e0 sept ans environ suivant le diagnostic. La maladie tire son nom de l’augmentation de la pression dans les vaisseaux pulmonaires et peut entra\u00eener une surcharge et une d\u00e9faillance de la partie droite du c\u0153ur. Les causes de l’hypertension pulmonaire peuvent \u00eatre diff\u00e9rentes, mais tous les patients luttent entre autres contre l’essoufflement ou une capacit\u00e9 de mouvement fortement r\u00e9duite. C’est pourquoi les chercheurs sont constamment \u00e0 la recherche de nouveaux moyens et de nouvelles th\u00e9rapies pour prolonger la vie des personnes souffrant d’hypertension pulmonaire et am\u00e9liorer leur confort.<\/p>\n

Cellules souches et hypertension pulmonaire<\/strong><\/h2>\n

Des m\u00e9decins allemands ont annonc\u00e9 le premier succ\u00e8s du traitement de l’hypertension pulmonaire par des cellules du sang de cordon ombilical (HUCMSC – human umbilical cord mesenchymal stem cell). La patiente \u00e9tait une fillette de trois ans souffrant d’HTAP et de la maladie de Rendu-Osler-Weber, \u00e0 laquelle on a inject\u00e9 par voie intraveineuse des cellules souches allog\u00e9niques provenant du sang du cordon ombilical de son petit fr\u00e8re. Les injections ont \u00e9t\u00e9 effectu\u00e9es cinq fois sur une p\u00e9riode de six mois. L’\u00e9tat clinique de la fillette a \u00e9t\u00e9 \u00e9valu\u00e9 \u00e0 deux et six mois. Non seulement aucun effet secondaire n’est apparu, mais on a \u00e9galement observ\u00e9 une augmentation de la capacit\u00e9 physique ainsi qu’une am\u00e9lioration des param\u00e8tres cardiovasculaires. Avant la perfusion de cellules souches, la jeune fille souffrait de troubles de la croissance et d’une prise de poids. Apr\u00e8s la premi\u00e8re perfusion, elle a commenc\u00e9 \u00e0 grandir – elle a gagn\u00e9 10 cm en trois mois. En outre, la fillette a maintenant six ans et se sent bien.<\/p>\n

Selon les chercheurs, la r\u00e9g\u00e9n\u00e9ration du syst\u00e8me vasculaire endommag\u00e9 par la maladie ainsi que l’att\u00e9nuation significative des dommages cellulaires sont responsables de l’am\u00e9lioration apport\u00e9e par la th\u00e9rapie par cellules souches de sang de cordon ombilical. L’\u00e9tude fait notamment \u00e9tat du r\u00f4le de la prostaglandine PGE2, qui pourrait jouer un r\u00f4le cl\u00e9 dans les capacit\u00e9s r\u00e9g\u00e9n\u00e9ratrices et immunomodulatrices des cellules souches issues du sang de cordon ombilical.<\/p>\n

Les chercheurs soulignent \u00e0 l’unanimit\u00e9 que des recherches suppl\u00e9mentaires devraient \u00eatre men\u00e9es et qu’il faudrait rechercher activement d’autres possibilit\u00e9s et utilisations pour les cellules souches d\u00e9riv\u00e9es du sang de cordon ombilical.<\/p>\n

Bibliographie:<\/p>\n

https:\/\/www.aabb.org\/news-resources\/news\/article\/2022\/07\/13\/cord-blood-derived-stem-cells-may-help-treat-pulmonary-hypertension<\/a><\/p>\n

https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1053249822018472<\/a><\/p>\n

https:\/\/www.nature.com\/articles\/s44161-022-00083-z<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Les cellules souches extraites du sang de cordon ombilical sont utilis\u00e9es comme traitement standard pour 80 maladies. Ces derni\u00e8res ann\u00e9es, de nouveaux rapports ont fait \u00e9tat de l’utilisation de ces cellules pour d’autres maladies. Des m\u00e9decins en Allemagne les ont utilis\u00e9es avec succ\u00e8s pour traiter l’hypertension pulmonaire chez une fillette de 3 ans.<\/p>\n","protected":false},"author":2,"featured_media":4699,"template":"","pregnancy_zone_category":[88],"class_list":["post-5863","pregnancy_zone","type-pregnancy_zone","status-publish","has-post-thumbnail","hentry","pregnancy_zone_category-news-fr"],"acf":[],"yoast_head":"\nSang de cordon et hypertension pulmonaire | FamiCord<\/title>\n<meta name=\"description\" content=\"Comment les cellules souches du sang de cordon ont aid\u00e9 une enfant atteinte d\u2019hypertension pulmonaire s\u00e9v\u00e8re.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/famicord.lu\/fr\/pregnancy-zone-2\/news-fr\/nabelschnurblut-rettet-maedchen-mit-schwerer-pulmonaler-hypertonie\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta 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